Introduction: Polycystic ovary disease is a common endocrine condition which is rapidly gaining epidemic proportions. No community based prevalence data is available for this syndrome in India. Materials and Methods: A cross-sectional community-based study was undertaken in a sampled census block of Mumbai to assess the prevalence of polycystic ovarian syndrome PCOS among adolescents and young girls aged years.
Among them, completed all clinical, ultrasonography USGand biochemical investigations. Nonobese comprised History of oligomenorrhea had a positive predictive value of Obese girls with PCOS were more hirsute, hypertensive, and had significantly higher mean insulin and 2 h post 75 g glucose levels compared with nonobese PCOS. Conclusion: To our knowledge, this is the first urban community-based study diagnosing PCOS and phenotypes among adolescent and young girls in India.
This study demonstrates that PCOS is an emerging disorder during adolescence and screening could provide opportunity to target the group for promoting healthy lifestyles and early interventions to prevent future morbidities. Rajiwade,Haritha Sagili,R. Motta International Journal of Clinical Practice.
Search Article. Users Online: A cross-sectional study of polycystic ovarian syndrome among adolescent and young girls in Mumbai, India. Indian J Endocr Metab ; Materials and Methods. Figure 1: Flow of study participants Click here to view. Table 1: Differences in the three groups of enrolled girls Click here to view.
Table 2: Difference in endocrine and metabolic profiles between polycystic ovarian synrdome and nonpolycystic ovarian synrdome Click here to view. Table 3: Polycystic ovarian synrdome phenotypes Click here to view. Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J Clin Endocrinol Metab ; Revised consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome.
Fertil Steril ; Position statement: Criteria for defining pcos as a predominantly hyperandrogenic syndrome: An Androgen Excess Society guideline. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: Hormonal and metabolic profile. Polycystic ovaries and associated clinical and biochemical features in young women.
Clin Endocrinol Oxf ;Study record managers: refer to the Data Element Definitions if submitting registration or results information. The symptoms of PCOS are anovulation, resulting in irregular menstruation amenorrhea and oligomenorrhea ovulation-related infertility, and polycystic ovaries, often associated with obesity, Type 2 diabetes, and high cholesterol levels.
It has also been recognized that some women with this syndrome will have PCO without clinical evidence of androgen excess, but will display evidence of ovarian dysfunction. It is believed to be that, the Hyperinsulinemia of PCOS stimulates the androgens production and increase the activity by decreasing the sex hormone binding globulin SHBG thus increasing the free active testosterone level and by the activating the cytochrome P C 17 alpha enzymatic system that controls androgens production.
The different diagnostic tests needed to adequately assess for the possibility of PCOS e. Oral contraceptives, Metformin and anti-androgens Spironolactone for the. All these management options are only for "acute" not for "chronic". The long-term management approach for the PCOS is needed which will be based on management of most affecting factor insulin resistance. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Search for terms x. COVID is an emerging, rapidly evolving situation. Save this study. Warning You have reached the maximum number of saved studies Furocyst - Poly Cystic Ovary Syndrome Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.
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Last Update Posted : September 15, Study Description. PCOS is a hormonal disorder that involves multiple organ systems within the body.Tuesday, June 23, Results from NIH-funded study could lead to improvements in diagnosis and treatment. The findings could provide important information on the possible causes of PCOS and for developing more effective ways to treat the condition.
PCOS is characterized by irregular or missing menstrual periods due to lack of or infrequent ovulationhigh levels of androgens male hormones and small cysts on the ovaries. Women with PCOS are also at higher risk of diabetes and heart disease. The current study analyzed the genes of nearly women who had irregular menstrual periods.
Researchers categorized them according to their body mass index BMI and levels of glucose, insulin and reproductive hormones, including androgens.
Their analysis revealed two PCOS subtypes, each associated with distinct groups of gene variants. This subtype also tended to have a lower BMI and lower insulin levels than the others. The remaining women had no clear combinations of traits but had a greater frequency of gene variants associated with PCOS, suggesting that this group may be distinct from the others.
Understanding the genes underlying these subtypes may yield new ways to diagnose PCOS and develop personalized treatments. The study was conducted by Andrea Dunaif, M. Esther Eisenberg, M. Dapas, M, et al. Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis.
PLOS Medicine. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www. Site Menu Home. Search Health Topics. Search the NIH Guide.Taxi driver quotes imdb
COVID is an emerging, rapidly evolving situation. News Releases. News Release Tuesday, June 23, Genetic analysis suggests distinct subtypes of polycystic ovary syndrome Results from NIH-funded study could lead to improvements in diagnosis and treatment. Back to Top.Background: Polycystic ovary syndrome PCOS is the most common endocrine disorder affecting women of reproductive age and is associated with obesity, hyperinsulinemia, and insulin resistance.
Because low carbohydrate diets have been shown to reduce insulin resistance, this pilot study investigated the six-month metabolic and endocrine effects of a low-carbohydrate, ketogenic diet LCKD on overweight and obese women with PCOS. They were instructed to limit their carbohydrate intake to 20 grams or less per day for 24 weeks.
Participants returned every two weeks to an outpatient research clinic for measurements and reinforcement of dietary instruction. There were non-significant decreases in insulin, glucose, testosterone, HgbA1c, triglyceride, and perceived body hair. Two women became pregnant despite previous infertility problems. Abstract Background: Polycystic ovary syndrome PCOS is the most common endocrine disorder affecting women of reproductive age and is associated with obesity, hyperinsulinemia, and insulin resistance.I suppose I could just update the previous postbut that feels wrong for some reason.
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Furocyst - Poly Cystic Ovary Syndrome Study
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The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study
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Genetic analysis suggests distinct subtypes of polycystic ovary syndrome
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